Potential immunologic effects of statins in cancer following transplantation

  title={Potential immunologic effects of statins in cancer following transplantation},
  author={James E. Fildes and Steven M. Shaw and Stephen G. Williams and Nizar N Yonan},
  journal={Cancer Immunology, Immunotherapy},
3-hydroxy-3-methyglutaryl CoA reductase inhibitors (statins) are frequently used following organ transplantation and have well reported pleiotropic effects, including immunomodulation, which may be of benefit in preventing graft rejection. However, the immunomodulatory effects of statins on cell transformation and malignancy, combined with the immunologic processes and administration of immunosuppression are almost completely unknown. The administration of immunosuppression is well recognised… CONTINUE READING