Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas.

@article{Injac2008PotentialHE,
  title={Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas.},
  author={Rade M. Injac and M Per{\vs}e and Nata{\vs}a Obermajer and Vukosava Djordjevic-Milic and Matev{\vz} Prijatelj and Aleksandar N. Djordjevic and Anton Cerar and B. Strukelj},
  journal={Biomaterials},
  year={2008},
  volume={29 24-25},
  pages={3451-60}
}
The aim of this study was to investigate the potential protective role of fullerenol C60(OH)24 on doxorubicin-induced liver toxicity using in vivo (female Sprague-Dawley rats) and in vitro (human hepatocellular carcinoma - HepG2; colorectal adenocarcinoma cell lines - Caco-2) approaches. The first (healthy control) and second (control with chemically induced mammary carcinomas) group received saline only. The third, fourth and fifth group (all with breast cancer) were injected (i.p.) with a… CONTINUE READING