Corpus ID: 12882485

Potential growth inhibitory effect of maitake D-fraction on canine cancer cells.

@article{Konno2004PotentialGI,
  title={Potential growth inhibitory effect of maitake D-fraction on canine cancer cells.},
  author={Sensuke Konno},
  journal={Veterinary therapeutics : research in applied veterinary medicine},
  year={2004},
  volume={5 4},
  pages={
          263-71
        }
}
  • S. Konno
  • Published 2004
  • Biology, Medicine
  • Veterinary therapeutics : research in applied veterinary medicine
The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types (CF33, CF21, and CL-1) of canine cancer cells was evaluated. The effect of D-fraction on several human cancer cells was also investigated. The effect of other beta-glucan products was likewise examined. D-fraction was highly effective on the canine cancer cells, either potently inhibiting cell growth or directly killing cells. Similar effects were also demonstrated in certain human cancer… 
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References

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TLDR
Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibiting of formation of the secondary focus due to metastasis of tumor cells in lymph and/or blood.
Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide).
TLDR
A bioactive beta-glucan from the Maitake mushroom has a cytotoxic effect, presumably through oxidative stress, on prostatic cancer cells in vitro, leading to apoptosis.
Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).
TLDR
D-fraction was found to potentiate the delayed-type hypersensitivity response which is associated with tumor growth suppression and indicates that stimulation of the immune response system triggered by the tumor-bearing state is activated by D- fraction.
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TLDR
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TLDR
The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity and results suggest that the anti-Diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fractions of peptidoglycan.
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TLDR
Heat-labile compounds strongly inhibiting adipocyte conversion proved to occur in fractions of molecular weight of more than 10,000 on the basis of activity measurement of glycerol-3-phosphate dehydrogenase.
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TLDR
Results indicate that the major chain of Grifola frondosa is made up of β-1, 6-linked glucose residues with branches of β, 3- linked glucose, and this glucan inhibited the growth of Sarcoma 180 tumor in ICR mice.
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    Alternative therapies in health and medicine
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TLDR
The data suggest that maitake mushrooms have the ability to alter lipid metabolism by inhibiting both the accumulation of liver lipids and the elevation of serum lipids.
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The fruit body of Grifola frondosa (maitake), Basidiomycetes, was confirmed to contain a substance with blood pressure-lowering activity and a hypotensive effect was observed on administration of reserpine, which suggests that the blood Pressure Lowering effect of maitake was brought about by a mechanism other than sympatholytic action.
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