Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.

  title={Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.},
  author={Kumar Kastury and Raffaele Baffa and Teresa Druck and Masataka Ohta and Maria Grazia Cotticelli and Hiroshi Inoue and Massimo Negrini and M Rugge and Dongqing Huang and Carlo M. Croce and Juan A Palazzo and Kay F Huebner},
  journal={Cancer research},
  volume={56 5},
A number of DNA fragments, identified by representational difference analysis, which were homozygously deleted in various cancer cell lines were previously mapped to human chromosomal arms. One of these, BE758-6, which was homozygously deleted in a number of colon carcinoma cell lines, had been mapped to chromosome region 3p. We have further localized the probe to 3p14.2, approximately 350kbp telomeric to the 3p14.2 break of the t(3;8) hereditary renal cell carcinoma chromosome translocation… CONTINUE READING


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