Potential functional roles of DNA demethylation intermediates.

  title={Potential functional roles of DNA demethylation intermediates.},
  author={Chun-Xiao Song and Chuan He},
  journal={Trends in biochemical sciences},
  volume={38 10},
DNA methylation in the form of 5-methylcytosine (5mC) is a key epigenetic regulator in mammals, and the dynamic balance between methylation and demethylation impacts various processes from development to disease. The recent discovery of the enzymatic generation and removal of the oxidized derivatives of 5mC, namely 5-hydroxymethylcysotine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in mammalian cells has led to a paradigm shift in our understanding of the demethylation process… CONTINUE READING

From This Paper

Figures and tables from this paper.


Publications citing this paper.
Showing 1-10 of 38 extracted citations

Aberrant gene-specific DNA methylation signature analysis in cervical cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine • 2017


Publications referenced by this paper.

Similar Papers

Loading similar papers…