Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer

@inproceedings{Strizzi2011PotentialFT,
  title={Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer},
  author={Luigi Strizzi and Katharine M. Hardy and Naira V. Margaryan and David W. Hillman and Elisabeth A. Seftor and Beiyun Chen and Xochiquetzal J. Geiger and E. Aubrey Thompson and Wilma L. Lingle and Cathy A. Andorfer and Edith A Perez and Mary J. C. Hendrix},
  booktitle={Breast Cancer Research},
  year={2011}
}
IntroductionThe re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal in a series of benign and malignant human breast tissues to determine the clinical significance of this expression and whether Nodal could represent a potential therapeutic target in breast cancer.MethodsTissue sections from 431 therapeutically naive patients diagnosed with… CONTINUE READING

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