Potential for biomolecular imaging with femtosecond X-ray pulses

  title={Potential for biomolecular imaging with femtosecond X-ray pulses},
  author={Richard Neutze and Remco R. Wouts and David van der Spoel and Edgar Weckert and Janos Hajdu},
Sample damage by X-rays and other radiation limits the resolution of structural studies on non-repetitive and non-reproducible structures such as individual biomolecules or cells. Cooling can slow sample deterioration, but cannot eliminate damage-induced sample movement during the time needed for conventional measurements. Analyses of the dynamics of damage formation suggest that the conventional damage barrier (about 200 X-ray photons per Å2 with X-rays of 12 keV energy or 1 Å wavelength) may… 

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