Potential for Tumorigenesis and Repair of Osteochondral Defects by iPS Cell Transplantation in Rat

@inproceedings{Mera2014PotentialFT,
  title={Potential for Tumorigenesis and Repair of Osteochondral Defects by iPS Cell Transplantation in Rat},
  author={Hisashi Mera and Junsei Takigami and Yoshihiro Tamamura and Maki Itokazu and Mitsuyoshi Yamazoe and Yusuke Hashimoto and Naoto Endo and Shigeyuki Wakitani},
  year={2014}
}
Articular cartilage repair remains a challenge in the field of orthopedic medicine. Cell-based therapy for cartilage repair, such as autologous chondrocyte implantation, was established in the 1990s. However, the issue of the source from which the lesion-targeting cells are harvested remains a limitation of this approach as larger lesions require more cells for repair, and thus, more healthy tissue must be damaged to harvest the needed cells. Reprogramming of induced pluripotent stem (iPS… CONTINUE READING