Potential errors in conventional DOT measurement techniques in shake flasks and verification using a rotating flexitube optical sensor

@inproceedings{Hansen2011PotentialEI,
  title={Potential errors in conventional DOT measurement techniques in shake flasks and verification using a rotating flexitube optical sensor},
  author={Sven Ulrik Hansen and Frank Kensy and Andreas K{\"a}ser and Jochen B{\"u}chs},
  booktitle={BMC biotechnology},
  year={2011}
}
BACKGROUND Dissolved oxygen tension (DOT) is an important parameter for evaluating a bioprocess. Conventional means to measure DOT in shake flasks using fixed Clark-type electrodes immersed in the bulk liquid are problematic, because they inherently alter the hydrodynamics of the systems. Other approaches to measure DOT that apply fluorescing sensor spots fixed at the inside wall of a shake flask are also suboptimal. At low filling volumes for cultivating microorganisms with a high oxygen… CONTINUE READING
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