Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.

@article{Khor1991PotentialEI,
  title={Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.},
  author={Soo Peang Khor and Michael Mayersohn},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1991},
  volume={19 2},
  pages={
          478-85
        }
}
Physiological pharmacokinetic models require the determination of tissue to blood distribution coefficients. A theoretical model has been developed and the resulting equations indicate that under certain conditions it is necessary to correct for the presence of drug in the residual blood remaining in the tissue. The potential error in ignoring this residual blood is expressed mathematically in terms of several important factors that include the anatomical features of the tissue (volume… CONTINUE READING

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