Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption.

@article{Wang2015PotentialEO,
  title={Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption.},
  author={Jing Wang and Tailang Yin and Yanqi Wen and Fuju Tian and Xiaojun He and Danni Zhou and Yi Lin and Jing Yang},
  journal={Reproduction, fertility, and development},
  year={2015}
}
Interferon regulatory factor (IRF) 4 has been reported to modulate Toll-like receptor (TLR) signalling. Polyinosinic-polycytidylic acid (poly(I:C)) can be specifically recognised by TLR3, triggering the innate immune response and subsequently resulting in pregnancy loss. In the present study, poly(I:C) was administered to mice with or without TLR3 blockade… CONTINUE READING