Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation.

@article{Salama2015PotentialDR,
  title={Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation.},
  author={Apolline Salama and Gw{\'e}na{\"e}lle Evanno and Jean Harb and Jean Paul Soulillou},
  journal={Xenotransplantation},
  year={2015},
  volume={22 2},
  pages={85-94}
}
Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc antibodies in human serum. However, Neu5Gc is expressed on mammal glycoproteins and glycolipids in most organs and cells. We review here the relevance of Neu5Gc and anti-Neu5Gc antibodies in the context of xenotransplantation and the use of animal-derived molecules and… CONTINUE READING
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Journal of the American Society of Nephrology : JASN • 2014
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O BLIXT, M KUMAGAI-BRAESCH, A TIBELL, CG GROTH, J. HOLGERSSON
Am J Transplant • 2009
View 1 Excerpt
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