Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase.

@article{Chung2010PotentialCE,
  title={Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase.},
  author={Seong Pil Chung and Kimiko Sogabe and Hwan Ki Park and Ying Song and Koji Ono and Rabab M Abou El-Magd and Yuji Shishido and Kazuko Yorita and Takashi Sakai and Kiyoshi Fukui},
  journal={Journal of biochemistry},
  year={2010},
  volume={148 6},
  pages={743-53}
}
D-amino acid oxidase (DAO) is a flavoenzyme that exists in the kidney, liver and brain of mammals. This enzyme catalyzes the oxidation of D-amino acids to the corresponding α-keto acid, hydrogen peroxide and ammonia. Recently D-serine, one of the substrates of DAO, has been found in the mammalian brain, and shown to be a co-agonist of the N-methyl-D-aspartate (NMDA) receptor in glutamate neurotransmission. In this study, we investigated the metabolism of extracellular D-serine and the effects… CONTINUE READING

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