Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.

@article{Zabala2015PotentialCO,
  title={Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.},
  author={Valerie Zabala and Ming Tong and Rosa Yu and Teresa Ram{\'i}rez and Emine Bihter Yalcin and Silvia Balbo and Elizabeth Silbermann and Chetram Deochand and Kavin M. Nunez and Stephen S Hecht and Suzanne de la Monte},
  journal={Alcohol and alcoholism},
  year={2015},
  volume={50 2},
  pages={118-31}
}
AIMS Alcoholic liver disease (ALD) is linked to binge drinking and cigarette smoking. Heavy chronic ± binge alcohol, or low-level exposures to dietary nitrosamines cause steatohepatitis with insulin resistance and oxidative stress in animal models. This study examines hepatotoxic effects of sub-mutagenic exposures to tobacco-specific nitrosamine (NNK) in relation to ALD. METHODS Long Evans rats were fed liquid diets containing 0 or 26% (caloric) ethanol (EtOH) for 8 weeks. In Weeks 3 through… CONTINUE READING
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