Potential clinical significance of plasma-based KRAS mutation analysis using the COLD-PCR/TaqMan(®) -MGB probe genotyping method.

@article{Liu2012PotentialCS,
  title={Potential clinical significance of plasma-based KRAS mutation analysis using the COLD-PCR/TaqMan(®) -MGB probe genotyping method.},
  author={Peijia Liu and Hongyan Liang and Li Xue and Chun Yang and Yang Liu and Kun Zhou and Xiaofeng Jiang},
  journal={Experimental and therapeutic medicine},
  year={2012},
  volume={4 1},
  pages={109-112}
}
Despite the improved ability to detect mutations in recent years, tissue specimens cannot always be procured in a clinical setting, particularly from patients with recurrence of tumors or metastasis. Therefore, the aim of this study was to investigate whether plasma is able to be used for mutation analysis instead of tissue specimens. We collected plasma from 62 patients with colorectal cancer (CRC) prior to treatment. DNA extracted from plasma and matched tumor tissues were obtained. Mutations… CONTINUE READING

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