Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer.

@article{Wang2010PotentialCS,
  title={Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer.},
  author={Shuhang Wang and Tongtong An and Jie Wang and Jun Zhao and Zhijie Wang and Minglei Zhuo and Hua Bai and Lu Yang and Yan Zhang and Xin Wang and Jianchun Duan and Yuyan Wang and Qingzhi Guo and Mei-na Wu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 4},
  pages={1324-30}
}
PURPOSE Non-small cell lung cancer (NSCLC) with KRAS mutation may be resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). This study aims to evaluate a plasma-based KRAS mutation analysis and the clinical significance of plasma KRAS mutation as a predictive marker for tumor resistance to EGFR-TKIs in patients with NSCLC. EXPERIMENTAL DESIGN DNA extracted from plasma and matched tumor tissues were obtained from 273 patients with advanced stage NSCLC. Patients… CONTINUE READING
45 Citations
24 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

: still an issue for open debate

  • SW Han, TY Kim, YK Jeon
  • Lung cancer
  • 2006

Similar Papers

Loading similar papers…