Potential cancer chemopreventive agents from Arbutus unedo.

@article{CarcacheBlanco2006PotentialCC,
  title={Potential cancer chemopreventive agents from Arbutus unedo.},
  author={Esperanza J Carcache-Blanco and Muriel Cuendet and Eun Jung Park and Bao-Ning Su and N. R. Farnsworth and John M Pezzuto and A Douglas Kinghorn},
  journal={Natural product research},
  year={2006},
  volume={20 4},
  pages={
          327-34
        }
}
A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of 1 was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in… CONTINUE READING
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