Potential biomarkers of osteonecrosis in Gaucher disease.

@article{Pavlova2011PotentialBO,
  title={Potential biomarkers of osteonecrosis in Gaucher disease.},
  author={Elena V. Pavlova and Patrick Deegan and Jane Tindall and I. McFarlane and Atul Mehta and Derralyn Hughes and James Edward Wraith and Timothy Martin Cox},
  journal={Blood cells, molecules & diseases},
  year={2011},
  volume={46 1},
  pages={27-33}
}
BACKGROUND To investigate the relationship between chemokines and cytokines and osteonecrosis in Gaucher disease, we conducted multiplex assays in a cohort of 100 adult patients. METHODS Mean age was 45 years (18-86); 92 Gaucher patients received imiglucerase (median duration 8 years (2-18)). Forty-three had experienced osteonecrosis (ON), and eight had ON despite enzyme therapy. Serum cytokines/chemokines were determined by fluorimetric bead arrays in samples from Gaucher patients and… CONTINUE READING

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