Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial.

@article{Goy2010PotentialBO,
  title={Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial.},
  author={Andre H. Goy and Steven H. Bernstein and Alice A McDonald and Michael D. Pickard and Hongliang Shi and Mark D Fleming and Barb Bryant and William L Trepicchio and Richard I. Fisher and Anthony L. Boral and George J. Mulligan},
  journal={Leukemia & lymphoma},
  year={2010},
  volume={51 7},
  pages={1269-77}
}
Immunohistochemical analyses of archival tumor specimens were used for pre-planned exploratory analyses of protocol-specified candidate biomarkers of bortezomib activity in 73 patients with relapsed/refractory mantle cell lymphoma in the phase 2 PINNACLE study. Consistent with other studies, elevated Ki-67 was a marker of poor prognosis, demonstrating significant associations with shorter time to progression and overall survival. Elevated NF-kappaB p65 and low PSMA5 expression demonstrated a… CONTINUE READING

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Sequential chemotherapy followed by high dose therapy and autologous stem cell rescue for mantle cell lymphoma: impact of MIB-1 on outcome abstract

  • AD Zelenetz, C Moskowitz, J Maragulia, CS Portlock, J. Teruya-Feldstein
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  • 2008
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