Potential biomarkers in predicting progression of epithelial hyperplastic lesions of the larynx.

@article{Gallo1997PotentialBI,
  title={Potential biomarkers in predicting progression of epithelial hyperplastic lesions of the larynx.},
  author={Oreste Gallo and Alessandro Franchi and Ilaria Chiarelli and Berardino Porfirio and Andrea Grande and Luigi Marco Simonetti and Corso Bocciolini and Omero Fini-Storchi},
  journal={Acta oto-laryngologica. Supplementum},
  year={1997},
  volume={527},
  pages={30-8}
}
Factors contributing to malignant transformation of laryngeal pre-neoplastic lesions remain largely unknown. Potential etiologic factors may be related to a genetically controlled sensitivity to environmental carcinogens. In this study, we investigated bleomycin-induced chromosome fragility in 15 patients with laryngeal keratoses who experienced a malignant transformation of pre-neoplastic lesions during follow-up, as compared with chromosome fragility in 15 historical controls with no… CONTINUE READING