Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.

@article{Yang2000PotentialBR,
  title={Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.},
  author={Samuel P. Yang and Adrian S Woolf and Hai-tao Yuan and Rodney J. Scott and Rupert Anthony Risdon and M J O'hare and Paul J. D. Winyard},
  journal={The American journal of pathology},
  year={2000},
  volume={157 5},
  pages={1633-47}
}
Transformations between epithelial and mesenchymal cells are widespread during normal development and adult disease, and transforming growth factor-beta1 (TGF-beta1) has been implicated in some of these phenotypic switches. Dysplastic kidneys are a common cause of chronic kidney failure in young children and result from perturbed epithelial-mesenchymal interactions. In this study, we found that components of the TGF-beta1 axis were expressed in these malformations: TGF-beta1 mRNA and protein… CONTINUE READING
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