• Corpus ID: 36752639

Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot.

  title={Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot.},
  author={Nuri Karadurmuş and Mustafa Şahin and Canturk Tasci and Ilkin Naharci and Cengiz Ozturk and Savas Ilbasmis and Zeki Dulkadir and Ahmet Şen and Kenan Sağlam},
  journal={Endokrynologia Polska},
  volume={61 3},
INTRODUCTION The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations. MATERIAL AND METHODS Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a… 

Figures and Tables from this paper

Blood glucose and lipid profile in patients with diabetic foot ulcer that underwent hyperbaric oxygen therapy

There is no significant effect of HBOT to decrease blood sugar, but the significant increase of lipid profile may be caused by the reaction of lipid peroxidation.

A Pilot Study of Short-Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine in Patients with Diabetic Foot Ulcer Wagner 3-4

The use of short-duration HBOT on DFU reduces HbA1c levels, leukocyte count, and serum creatinine levels better than standard therapy alone and this protocol would save time and effort in future HBOT implementation.

The Effects of Hyperbaric Oxygen Therapy on Blood Glucose Levels and Lipid Profile in Diabetes Mellitus Patients

There is a significant decrease in blood glucose level and lipid profile (total cholesterol, and triglycerides) after hyperbaric oxygen therapy.

Role of Hyperbaric Oxygen Therapy on Microvascular Diabetic Complications and Metabolic Profile among Patients with Type 2 Diabetes Mellitus

Findings from animal (rat) studies indicate that the periodic HBOT exposure limits some of the damage associated with the chronic high blood glucose levels, particularly those mediated through oxidative pathways.

Hyperbaric Oxygen Therapy to Reduce Blood Glucose Level on Patients Diabetes Mellitus

There was the influence of hyperbaric oxygen therapy with decreasing blood glucose level, and there are improvements pancreatic beta cell function and increased tissue sensitivity to insulin due to increased oxidative phosphorylation process in pancreatic Beta-cell mitochondria to increase ATP production in Pancic beta cells.

Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies.

It is suggested that hyperbaric oxygen therapy (HBOT) could be used as a therapeutic intervention for type 2 diabetes and show that HBOT ameliorates glucose tolerance in diabetic patients.

Hyperbaric Oxygen Therapy and Vascular Complications in Diabetes Mellitus

Hyperbaric oxygen therapy affects molecules involved in the regulation of nitric oxide synthesis and in that way exerts anti-inflammatory and angiogenic effects in patients with DM, and the recent literature related to the effects of HBOT is explored.

Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers: A Randomized Controlled Trial

Adjunctive HBOT improved wound healing in persons with DFU and reduced the risk of amputation of the affected limb, and at least 20 HBOT sessions are required to be effective.

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines, and the anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα.



The relationship between glycemic control and platelet activity in type 2 diabetes mellitus.

Hyperbaric Oxygen Therapy Mediates Increased Nitric Oxide Production Associated With Wound Healing: A Preliminary Study

A significant increase in local wound NO levels (by NOx measurements) after successful HBOT is documents and suggests that this mechanism may be an important factor in promoting enhanced wound healing and wound closure associated with this therapy.

Hyperbaric oxygen reduces the progression and accelerates the regression of atherosclerosis in rabbits.

It is concluded that repeated, but relatively short, exposure to HBO induces an antioxidant defense mechanism(s) that is responsible for retarding the development or accelerating the regression of atherosclerotic lesions.

The effect of hyperbaric oxygen therapy on blood vessel function in diabetes mellitus.

Endothelial dysfunction and pathogenesis of diabetic angiopathy.

Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS.

The findings suggest that the beneficial effects of HBO in treating I/R injury may be mediated in part by inhibition of ICAM-1 expression through the induction of eNOS.

Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease

The treatment was found to inhibit neuronal death, arrest the progression of radiation-induced neurologic necrosis, improve blood flow in regions affected by chronic neurologic disease as well as aerobic metabolism in brain injury, and accelerate the resolution of clinical symptoms.