Potential benefits of cyproheptadine in HIV-positive patients under treatment with antiretroviral drugs including efavirenz

@article{Dabaghzadeh2012PotentialBO,
  title={Potential benefits of cyproheptadine in HIV-positive patients under treatment with antiretroviral drugs including efavirenz},
  author={Fatemeh Dabaghzadeh and Hossein Khalili and Padideh Ghaeli and Simin Dashti-Khavidaki},
  journal={Expert Opinion on Pharmacotherapy},
  year={2012},
  volume={13},
  pages={2613 - 2624}
}
Introduction: More than 50% of HIV-positive patients experience neuropsychiatric adverse reactions following efavirenz therapy. Discontinuation of efavirenz due to its neuropsychiatric side effects has been reported in 2 – 13% of patients. Dizziness, headache, nightmares, abnormal dreams, mild cognitive difficulty, sleep disturbance (somnolence and insomnia), impaired concentration, depression, hallucination, delusion, paranoia, anxiety, agitation, aggressive behavior, mania, emotional… 
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Citation Type

Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs
TLDR
The evolving molecular mechanistic basis of NPAEs and abuse of efavirenz point to a complex and polymodal receptor pharmacology, and possible contributions of the mitochondrial-immune-inflammatory-redox cascade are explored in the context of the signaling mechanisms that appear to be involved.
RE: Severe mental illness at ART initiation is associated with worse retention in care among HIV‐infected Ugandan adults by JM Nachega et al. (2013), TMIH 18, pp 53–57
  • S. Kapoor
  • Psychology, Medicine
    Tropical medicine & international health : TM & IH
  • 2014
TLDR
The general consensus is that efavirenz may alter cytokine levels that may contribute to the development of these psychiatric symptoms and the CD4 lymphocyte counts as well as the ‘viral load’ have a significant influence on the severity ofThese psychiatric effects.
Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial
TLDR
A significant higher body mass index was observed among CH-treated patients after 8 weeks intervention with cyproheptadine compared with the control group (P<0.041).
Associated factors of sleep quality in HIV-positive individuals
TLDR
Depression, anxiety and physical morbidity were detected as main factors that affect sleep quality in the HIV-positive individuals.
Fatigue in Healthy and Diseased Individuals
TLDR
Fatigue needs to be recognized as an important condition that is not only a symptom but may also be quantified and can be modified by various measures depending on the underlying cause.
Psychiatry and Neurology
LGBTQ individuals seeking mental or behavioral health care may present with similar complaints and stressors as their heterosexual counterparts, yet LGBT persons experience poorer mental health…
Role of Cyproheptadine in Various Psychiatric Conditions

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