Potential beneficial effects of potassium channel blockade by tedisamil in isolated perfused working rat heart with coronary artery ligation

@article{Duchosal2004PotentialBE,
  title={Potential beneficial effects of potassium channel blockade by tedisamil in isolated perfused working rat heart with coronary artery ligation},
  author={F. Duchosal and Lionel Henry Opie},
  journal={Cardiovascular Drugs and Therapy},
  year={2004},
  volume={6},
  pages={329-336}
}
Tedisamil, a potassium channel blocker, is known to produce bradycardia. The hypothesis tested was that tedisamil-induced bradycardia should improve the mechanical and metabolic properties of the ischemic myocardium. Using isolated perfused rat heart with coronary-artery ligation, tedisamil was compared with alinidine, verapamil, and propranolol. The end points were myocardial mechanical function and oxygen uptake. In coronary-ligated hearts, tedisamil (1.83×10-6 M) decreased heart rate… CONTINUE READING