Potential applications for rhIGF-I: Bone disease and IGFI.

@article{Bahamonde2020PotentialAF,
  title={Potential applications for rhIGF-I: Bone disease and IGFI.},
  author={Marisol Bahamonde and Madhusmita Misra},
  journal={Growth hormone \& IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2020},
  volume={52},
  pages={
          101317
        }
}
  • M. Bahamonde, M. Misra
  • Published 23 March 2020
  • Medicine, Biology
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
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TLDR
These data demonstrate that osteopenic women with anorexia nervosa treated withrhIGF-I showed more beneficial changes in bone density, compared with patients not treated with rhIGf-I, which is not sufficient to improve bone density in undernourished patients.
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It is hypothesized that short term administration of recombinant human IGF-I (rhIGF-I) would increase bone turnover in young women with anorexia nervosa and there was a significant increase in markers of bone formation, as assessed by both PICP and OC.
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    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
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In this patient with severe insulin resistance, therapy with rhIGF-I resulted in beneficial effects on Si, body composition, bone size, and linear growth, which have implications for IGF-I therapy in a variety insulin resistant states.
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Short-term improvements in IGF-1 z scores predicted recovery of bone and muscle outcomes following initiation of anti-TNF-α therapy in pediatric CD, and suggest that disease effects on growth hormone metabolism contribute to musculoskeletal deficits in CD.
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