• Corpus ID: 34762558

Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.

  title={Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.},
  author={Aldo Andreani and Alessandra Locatelli and Mirella Rambaldi and Alberto Leoni and Rosaria Bossa and A Fraccari and Iraklis Galatulas},
  journal={Anticancer research},
  volume={16 6B},
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one unsubstituted NH group, are promising candidates for further investigation. 
13 Citations

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