Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine.

@article{Andreani1996PotentialAA,
  title={Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine.},
  author={Aldo Andreani and Mirella Rambaldi and Alberto Leoni and Alessandra Locatelli and Rosaria Bossa and A Fraccari and Iraklis Galatulas and Giofr{\`e} Salvatore},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 14},
  pages={
          2852-5
        }
}
In connection with a previous research dealing with the antitumor activity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports the synthesis of new derivatives which were tested for antitumor and positive inotropic activity. In most cases the cytotoxic data from the in vitro experiments (HeLa) were in agreement with the antitumor data in vivo (Ehrlich). The active compounds bear a phenyl ring at the 6 position. On the other hand, the most active cardiotonic agents were devoid of the… 

Potential antitumor agents. 34.(1) Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from diimidazo[1,2-a: 1,2-c] pyrimidine.

TLDR
Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described and are now under review by BEC.

Improved antiproliferative activities of a new series of 1,3,4-thiadiazole derivatives against human leukemia and breast cancer cell lines

TLDR
Twenty-two novel 1,3,4-thiadiazole derivatives were synthesized using different aromatic acids as starting materials, followed by cyclization, coupling and deprotection reaction, and results suggest that most of the target compounds exhibit potent anti-proliferative activities.

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.