Potential antitumor agents. 21. Structure determination and antitumor activity of imidazo[2,1-b]thiazole guanylhydrazones.

  title={Potential antitumor agents. 21. Structure determination and antitumor activity of imidazo[2,1-b]thiazole guanylhydrazones.},
  author={Aldo Andreani and Mirella Rambaldi and Alessandra Locatelli and Rosaria Bossa and A Fraccari and Iraklis Galatulas},
  journal={Journal of medicinal chemistry},
  volume={35 24},

Reactions of MoOCl4 and MoO2Cl2 with Heterocyclic Thioamides

MoOCl4/MoO2Cl2 were reacted with 2-mercaptopyridine (IUPAC: pyridine-2-thiol)/4phenylimidazole-2-thiol (IUPAC: 4-phenyl-1,3-dihydroimidazole-2-thione)/6-mercaptopurine (IUPAC:

Reactions of MoO2Cl2 and MoOCl4 with 2-Mercaptopyridine, 4-Phenylimidazole-2-thiol and 6-Mercaptopurine Monohydrate

MoO2Cl2/MoOCl4 have been reacted with 4-phenylimidazole-2-thiol/6-mercaptopurine monohydrate/2-mercaptopyridine in acetonitrile solvent in unimolar/bimolar proportions at room temperature. The

Diversity‐Oriented Synthesis of Spirooxindoles Using Surface‐Modified TiO2 Nanoparticles as Heterogeneous Acid Catalyst

An efficient and diversity oriented synthetic protocol has been presented to synthesize spirooxindoles using isocyanide based multicomponent reaction in the presence of surface modified TiO2

Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities

We have synthesized some imidazo[2,1-b]thiazole derivatives by reaction of 1-(2-amino-4-methylthiazol-5-yl)ethanone or ethyl 2-amino-4-methylthiazole-5-carboxylate with α-bromo aralkyl ketones

Exploring Novel Anticancer Approaches: Design, Synthesis and Biological Evaluation of Small Molecules and NGR Tumor-Homing Peptides

A library of C-terminus and N- terminus functionalized cCNGRC peptides was designed and synthesized with the aim to confirm the importance of N-terminal amine group of the cC NGRC in the APN binding and showed the capability to selectively stabilize a specific G4 structure and to inhibit cancer cell growth in the nanomolar range.

Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of N-Fused Benzo[4,5]imidazo[2,1-b]thiazole Derivatives via Substituted trans-1,2-Diiodoalkenes, 1H-Benzo[d]imidazole-2-thiols, and Halobenzenes.

Two transition metal (Cu and Pd)-catalyzed C-S, C-N, and C-C bond cross-coupling reactions for the preparation of N-fused benzo[4,5]imidazo[2,1-b]thiazole derivatives were developed and synthesized in moderate to excellent yields.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

The present investigation led to the identification of potent G-quadruplex stabilizers with high selectivity over duplex DNA and preference for one G- quadruplex topology over others.