Potential antimalarial lead structures from fungi of marine origin.

@article{Wright2005PotentialAL,
  title={Potential antimalarial lead structures from fungi of marine origin.},
  author={Anthony David Wright and Naomi Lang-Unnasch},
  journal={Planta medica},
  year={2005},
  volume={71 10},
  pages={964-6}
}
Antiplasmodial and cytotoxicity testing of five highly oxygenated natural products (6R,12R,14R-colletoketol, 6R,11R,12R,14R-colletoketodiol, dihydrobotrydial, pycnidione, and 3R,4S-hydroxymellein), all derived from fungi of marine origin, showed one of them, pycnidione, to have activities against three different strains of Plasmodium falciparum in the sub-micromolar (microM) range. Although the mean selectivity index of 1 for the observed antiplasmodial activity of 4 is low, pycnidione's… CONTINUE READING

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