Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties.

@article{Cordi2001PotentialAD,
  title={Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties.},
  author={Alex A. Cordi and Isabelle Berque-Bestel and Thierry Persigand and Jean Michel Lacoste and Adrian Newman-Tancredi and Val{\'e}rie Audinot and Mark J. Millan},
  journal={Journal of medicinal chemistry},
  year={2001},
  volume={44 5},
  pages={
          787-805
        }
}
  • Alex A. Cordi, Isabelle Berque-Bestel, +4 authors Mark J. Millan
  • Published in
    Journal of medicinal…
    2001
  • Chemistry, Medicine
  • Classical antidepressants are thought to act by raising monoamine (serotonin and noradrenaline) levels in the brain. This action is generally accomplished either by inhibition of monoamine metabolism (MAO inhibitors) or by blockade of monoamine uptake (tricyclic antidepressants and selective serotonin or noradrenaline reuptake inhibitors). However, all such agents suffer from a time lag (3--6 weeks) before robust clinical efficacy can be demonstrated. This delay may reflect inhibitory actions… CONTINUE READING

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