Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.

@article{Hong1970PotentialAA,
  title={Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.},
  author={C. Hong and C. Piantadosi and J. Irvin},
  journal={Journal of pharmaceutical sciences},
  year={1970},
  volume={59 11},
  pages={
          1637-45
        }
}
A series of 5-substituted pyrimidine-6-carboxaldehydes and their derivatives were synthesized and tested for inhibition of growth of the Ehrlich ascites carcinoma and Ehrlich carcinoma. Further studies included inhibition of incorporation of L-phenylalanine-1-14C and formate-14C into proteins, and orotic acid -5-3H, thymidine-2-14C, and formate-14C into nucleic acids of the ascitic tumor cells in vitro. The following compounds were found to be particularly active as inhibitors: 2-mercapto-4… Expand
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