• Corpus ID: 55029142

Potential antibacterial drug targets for Quercetin and Rutin: An in silicostudy using AutoDock

@inproceedings{Ragunathan2015PotentialAD,
  title={Potential antibacterial drug targets for Quercetin and Rutin: An in silicostudy using AutoDock},
  author={Adhithya Ragunathan and Lokesh Ravi},
  year={2015}
}
In this study, we analysed the possible antibacterial drug target and mode of action of quercetin and rutin against Staphylococcus aureus. These flavonoid compounds commonly found in many plants and trees are well known for its antibacterial activity. Eight protein molecules from S.aureus, belonging to various pathways to its cell survivability were chosen. These protein molecules were docked with quercetin and rutin to find the most significant protein target. Quercetin exhibited lowest… 

Rutin, a Natural Inhibitor of IGPD Protein, Inhibits the Biofilm Formation in Staphylococcus xylosus ATCC700404

Evidence is provided that rutin is a natural drug that has the ability to interfere with the formation of biofilm in S. xylosus and is therefore a potential enzyme inhibitor of IGPD.

In Silico Study of Avocado (Persea americana Mill.) Seed Compounds Against PBP2a Receptor on Staphylococcus aureus

The nosocomial infection causes 1,4 million mortality every day in the world. International Nosocomial Infection Control Consortium (INICC) data shows that 84,4% nosocomial infection is caused by S.

Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation in Staphylococcus xylosus ATCC700404 in vitro and in vivo

It is confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, and new insights into the treatment of biofilm mediated persistent infections and chronic bacterial infections are provided.

Bioactivity guided extraction of PDHC [3,3’-(propane-2,2-diyl)bis(3,4,5,6,7,8- hexahydro-1h-isochromene)]: A Novel antibacterial compound from an ornamental plant Polyalthia longifolia

PHDC is a novel compound extracted from Polyalthia longifolia showed significant antibacterial effect and it is suggested that the compound can be further used as lead molecules to overcome the infections caused by antibiotic resistant bacteria.

Anti-Proteus Activity, Anti-Struvite Crystal, and Phytochemical Analysis of Sida acuta Burm. F. Ethanolic Leaf Extract

Proteus mirabilis is a significant cause of urinary tract infection that may contribute to struvite stones. Anti-infection of this bacterium and anti-struvite formation must be considered. Sida acuta

Novel Pyrimidines as Multitarget Protein Tyrosine Kinase Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Investigating a new class of pyrimidine derivatives identified as potent protein tyrosine kinase (PTK) inhibitors for the treatment of idiopathic pulmonary fibrosis suggested that the multi‐PTK inhibitor 6 a may serve as a promising agent for the Treatment of IPF.

Role of Indole Production on Virulence of Vibrio cholerae Using Galleria mellonella Larvae Model

An indole negative mutant strain was constructed using transposon mutagenesis and the direct effect of indole on the virulence of V. cholerae was evaluated using Galleria mellonella larvae model which regained its virulence after complementation with exogenous indole.

Antibiotic Resistance Profiles and Quorum Sensing-Dependent Virulence Factors in Clinical Isolates of Pseudomonas Aeruginosa

The results showed a high incidences of antibiotic resistance and virulence properties in P. aeruginosa, and indicate that the clinical use of QS-inhibitory drugs that appear superior to conventional antimicrobials by not exerting any selective pressure on resistant strains.

References

SHOWING 1-5 OF 5 REFERENCES

Efficient Unbound Docking of Rigid Molecules

A new algorithm for unbound (real life) docking of molecules, whether protein-protein or protein-drug, carrying out rigid docking, with surface variability/flexibility implicitly addressed through liberal intermolecular penetration is presented.

International Journal of Antimicrobial Agents

Microbiological Research

  • Biology
    Nature
  • 1959

Sorboa; S Giordanoa; L Ricciardib; S F erraraa; D Montesanoc; RC Cobianchia; ML Vuottob; L Ferrarac

  • Fitoterapia,
  • 2000

A Zervosen; S In glis; A Martins; O Verlaine; A Rydzik; V Job; A Luxen; B Joris; CJ Schofield; A Dessen

  • ACS Chem Biol,
  • 2011