Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.

@article{Nagasawa2014PotentialAE,
  title={Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.},
  author={Ikuko Nagasawa and Akira Kaneko and Toshihiro Suzuki and Kazuto Nishio and Kaoru Kinoshita and M Shiro and Kiyotaka Koyama},
  journal={Journal of natural products},
  year={2014},
  volume={77 4},
  pages={
          963-8
        }
}
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical… 
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TLDR
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Prenylated p-Terphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ-5.
TLDR
Nine previously undescribed prenylated p-terphenyls,Prenylterphenyllins F-J and prenyloncandidusins D-G, isolated from an endophytic fungus, Aspergillus candidus LDJ-5, were determined from NMR and MS data.
Suppressive effects of polyozellin on endothelial protein C receptor shedding via inhibiting TACE activity and MAP kinases.
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The potential of polyozellin is demonstrated as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shed.
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