Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.

  title={Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.},
  author={Ikuko Nagasawa and A. Kaneko and T. Suzuki and K. Nishio and K. Kinoshita and Motto Shiro and K. Koyama},
  journal={Journal of natural products},
  volume={77 4},
  • Ikuko Nagasawa, A. Kaneko, +4 authors K. Koyama
  • Published 2014
  • Chemistry, Medicine
  • Journal of natural products
  • One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical… CONTINUE READING
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