Potential action of IGF-1 and EGF on androgen receptor nuclear transfer and transactivation in normal and cancer human prostate cell lines.

@article{Orio2002PotentialAO,
  title={Potential action of IGF-1 and EGF on androgen receptor nuclear transfer and transactivation in normal and cancer human prostate cell lines.},
  author={Francesco Orio and B{\'e}atrice T{\'e}rouanne and Virginie Georget and Serge Lumbroso and Christophe Avanc{\`e}s and Christian Siatka and Charles S Sultan},
  journal={Molecular and cellular endocrinology},
  year={2002},
  volume={198 1-2},
  pages={105-14}
}
This work was designed to determine whether IGF-1 and EGF modulate nuclear transfer and transactivation of the androgen receptor (AR) in human prostate cell lines (PNT1A and DU-145). We first characterized the IGF-1 and EGF receptors by ligand-binding assays with [125I] IGF-1 and [125I] EGF in a normal human prostate epithelial cell line, PNT1A. We then evaluated the effects of these growth factors on AR nuclear transfer and transcriptional activation in this cell line and in DU-145, a human… CONTINUE READING

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