Potential Vulnerabilities of Neuronal Reward, Risk, and Decision Mechanisms to Addictive Drugs

@article{Schultz2011PotentialVO,
  title={Potential Vulnerabilities of Neuronal Reward, Risk, and Decision Mechanisms to Addictive Drugs},
  author={Wolfram Schultz},
  journal={Neuron},
  year={2011},
  volume={69},
  pages={603-617}
}
How do addictive drugs hijack the brain's reward system? This review speculates how normal, physiological reward processes may be affected by addictive drugs. Addictive drugs affect acute responses and plasticity in dopamine neurons and postsynaptic structures. These effects reduce reward discrimination, increase the effects of reward prediction error signals, and enhance neuronal responses to reward-predicting stimuli, which may contribute to compulsion. Addictive drugs steepen neuronal… CONTINUE READING
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