Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

@article{Zhang2016PotentialTO,
  title={Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture},
  author={Xuan Zhang and Erik R. Abels and Jasmina S. Redzic and Julia Margulis and Steve Finkbeiner and Xandra O Breakefield},
  journal={Cellular and Molecular Neurobiology},
  year={2016},
  volume={36},
  pages={459-470}
}
In Huntington’s disease (HD) the imperfect expanded CAG repeat in the first exon of the HTT gene leads to the generation of a polyglutamine (polyQ) protein, which has some neuronal toxicity, potentially mollified by formation of aggregates. Accumulated research, reviewed here, implicates both the polyQ protein and the expanded repeat RNA in causing toxicity leading to neurodegeneration in HD. Different theories have emerged as to how the neurodegeneration spreads throughout the brain, with one… CONTINUE READING
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