Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis

  title={Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis},
  author={R. Franco and C. Bortner and J. Cidlowski},
  journal={The Journal of Membrane Biology},
  • R. Franco, C. Bortner, J. Cidlowski
  • Published 2005
  • Medicine, Chemistry
  • The Journal of Membrane Biology
  • Apoptosis is characterized by the programmed activation of specific biochemical pathways leading to the organized demise of cells. To date, aspects of the intracellular signaling machinery involved in this phenomenon have been extensively dissected and characterized. However, recent studies have elucidated a novel role for changes in the intracellular milieu of the cells as important modulators of the cell death program. Specially, intracellular ionic homeostasis has been reported to be a… CONTINUE READING
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