Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis

  title={Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis},
  author={Rodrigo Franco and Carl D. Bortner and John A. Cidlowski},
  journal={The Journal of Membrane Biology},
Apoptosis is characterized by the programmed activation of specific biochemical pathways leading to the organized demise of cells. To date, aspects of the intracellular signaling machinery involved in this phenomenon have been extensively dissected and characterized. However, recent studies have elucidated a novel role for changes in the intracellular milieu of the cells as important modulators of the cell death program. Specially, intracellular ionic homeostasis has been reported to be a… 
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Regulation and critical role of potassium homeostasis in apoptosis
  • S. Yu
  • Biology
    Progress in Neurobiology
  • 2003
Activation of K+ channels: an essential pathway in programmed cell death.
The targeting of K+ channels are discussed as a potential therapeutic tool in modulating apoptosis to maintain the balance between cell proliferation and cell death that is essential to the normal development and function of an organism.
Plasma Membrane Depolarization without Repolarization Is an Early Molecular Event in Anti-Fas-induced Apoptosis*
Diverse apoptotic stimuli caused a rapid cellular depolarization of Jurkat T-cells that occurs prior to and after cell shrinkage, and the inability of cells to repolarize via inhibition of the Na+/K+-ATPase is a likely regulatory component of the death process.
Plasma membrane potential in thymocyte apoptosis.
It is found that blockade of plasma membrane K+ channels by tetrapentylammonium (TPA), which leads to a DeltaP sip collapse, can prevent the thymocyte apoptosis induced by exposure to the glucocorticoid receptor agonist dexamethasone, the topoisomerase inhibitor etoposide, gamma-irradiation, or ceramide.
A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis*
Analysis of K+ and Na+ ion content of individual cells by flow cytometry revealed that the intracellular ionic strength of apoptotic cells decreased substantially from their non-shrunken counterparts, and data show that the efflux of ions plays a necessary and perhaps a pivotal role in the cell death program.
Apoptosis and cell death channels in prostate cancer.
Cation channels trigger apoptotic death of erythrocytes
Osmotic and oxidative stress open Ca2-permeable cation channels in erythrocytes, thus increasing cytosolic Ca2+ activity and triggering ery Throcyte apoptosis.
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The intracellular mechanisms underlying the sensing of cell volume perturbations and the activation of volume compensatory processes, commonly summarized as regulatory volume decrease (RVD), are revealed.
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This review summarizes the results of recent analysis of the PMCA dysregulation in diseased cells or model systems of pathological conditions, including both acute disorders like hypoxia/ischemia and seizure, and slowly progressing dysfunctions like Alzheimer's disease, hypertension, diabetes and aging.
Cation channels, cell volume and the death of an erythrocyte
Beyond their role in the limitation of erythrocyte survival, cation channels may contribute to the triggering of apoptosis in nucleated cells exposed to osmotic shock and/or oxidative stress.