Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis

@article{Franco2005PotentialRO,
  title={Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis},
  author={Rodrigo Franco and Carl D. Bortner and John A. Cidlowski},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={209},
  pages={43-58}
}
Apoptosis is characterized by the programmed activation of specific biochemical pathways leading to the organized demise of cells. To date, aspects of the intracellular signaling machinery involved in this phenomenon have been extensively dissected and characterized. However, recent studies have elucidated a novel role for changes in the intracellular milieu of the cells as important modulators of the cell death program. Specially, intracellular ionic homeostasis has been reported to be a… 
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