Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?

@article{Smyk2013PotentialRF,
  title={Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?},
  author={Daniel S. Smyk and Eirini I Rigopoulou and Dimitrios P Bogdanos},
  journal={Current infectious disease reports},
  year={2013},
  volume={15 1},
  pages={14-24}
}
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease serologically characterized by the presence of high-titer antimitochondrial antibodies and, histologically by chronic nonsuppurative cholangitis and granulomata. The aetiology of the disease remains elusive, although genetic, epigenetic, environmental, and infectious factors have been considered important for the induction of the disease in genetically prone individuals. The disease shows a striking female predominance… CONTINUE READING

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