Potential Role of the a 4 and a 6 Nicotinic Receptor Subunits in Regulating Nicotine-Induced Seizures 1

@inproceedings{Stitzel2000PotentialRO,
  title={Potential Role of the a 4 and a 6 Nicotinic Receptor Subunits in Regulating Nicotine-Induced Seizures 1},
  author={Jerry A. Stitzel and Melissa Jimenez and Michael J. Marks and Theresa Tritto and Allan C. Collins},
  year={2000}
}
Several studies have shown that genetic factors influence sensitivity to nicotine-induced seizures in the mouse. We used recombinant inbred (RI) strains derived from the Long-Sleep (LS) and Short-Sleep (SS) mouse lines to assess the possibility that polymorphisms associated with one or more of the nicotinic receptors cosegregate with differential sensitivity to nicotine-induced seizures. Restriction fragment length polymorphisms (RFLPs) associated with the a2, a3, a4, a5, and a6 nicotinic… CONTINUE READING