Potential Role of Transient Receptor Potential Channel M5 in Sensing Putative Pheromones in Mouse Olfactory Sensory Neurons

@inproceedings{Oshimoto2013PotentialRO,
  title={Potential Role of Transient Receptor Potential Channel M5 in Sensing Putative Pheromones in Mouse Olfactory Sensory Neurons},
  author={Arisa Oshimoto and Yoshihiro Wakabayashi and Anna K. Garske and Roberto L{\'o}pez and Shane H Rolen and Michael G Flowers and Nicole L. Arevalo and Diego Restrepo},
  booktitle={PloS one},
  year={2013}
}
Based on pharmacological studies of chemosensory transduction in transient receptor potential channel M5 (TRPM5) knockout mice it was hypothesized that this channel is involved in transduction for a subset of putative pheromones in mouse olfactory sensory neurons (OSNs). Yet, in the same study an electroolfactogram (EOG) in the mouse olfactory epithelium showed no significant difference in the responses to pheromones (and odors) between wild type and TRPM5 knockout mice. Here we show that the… CONTINUE READING

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