Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

  title={Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections},
  author={H. Terunuma and X. Deng and Z. Dewan and S. Fujimoto and N. Yamamoto},
  journal={International Reviews of Immunology},
  pages={110 - 93}
  • H. Terunuma, X. Deng, +2 authors N. Yamamoto
  • Published 2008
  • Biology, Medicine
  • International Reviews of Immunology
  • Natural killer (NK) cells recognize tumor cells and virus-infected cells and attack without being sensitized to antigens. The development of the antitumor/antivirus activities of NK cells is controlled by multiple mechanisms such as direct cytotoxic activity against target cells, antibody-dependent cell-mediated cytotoxicity, secretion of Th1-type cytokines, and interactions with dendritic cells. The development of these activities plays a significant role in both innate and adaptive immunities… CONTINUE READING
    79 Citations
    Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications
    • 173
    • PDF
    Natural Killer Cells in Cancer: An Overview
    • PDF
    Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells.
    • 25
    NK cell-based autologous immune enhancement therapy (AIET) for cancer
    • 16
    • PDF
    Natural killer cell‐based immunotherapy in cancer: current insights and future prospects
    • 183
    Next-Generation Immunotherapies to Improve Anticancer Immunity
    • PDF
    Natural killer cells as a promising tool to tackle cancer—A review of sources, methodologies, and potentials
    • 4
    Natural Killer Cells in Hepatitis C Virus Infection
    • Highly Influenced
    • PDF


    A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
    • 212
    • PDF
    Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
    • 1,123
    • Highly Influential
    Close encounters of different kinds: Dendritic cells and NK cells take centre stage
    • 541
    • Highly Influential
    NK cell and DC interactions.
    • 461
    Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    • 175
    • PDF
    Role of human natural killer cells in health and disease.
    • 168
    • PDF
    Dendritic cell immunotherapy: mapping the way
    • 965
    • PDF
    Potential role of natural killer cells in controlling growth and infiltration of AIDS‐associated primary effusion lymphoma cells
    • 16