Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

@article{Terunuma2008PotentialRO,
  title={Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections},
  author={Hiroshi Terunuma and Xuewen Deng and Zahidunnabi Dewan and Shigeyoshi Fujimoto and Naoki Yamamoto},
  journal={International Reviews of Immunology},
  year={2008},
  volume={27},
  pages={110 - 93}
}
Natural killer (NK) cells recognize tumor cells and virus-infected cells and attack without being sensitized to antigens. The development of the antitumor/antivirus activities of NK cells is controlled by multiple mechanisms such as direct cytotoxic activity against target cells, antibody-dependent cell-mediated cytotoxicity, secretion of Th1-type cytokines, and interactions with dendritic cells. The development of these activities plays a significant role in both innate and adaptive immunities… 
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