Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

@article{Terunuma2008PotentialRO,
  title={Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections},
  author={Hiroshi Terunuma and Xuewen Deng and Zahidunnabi Dewan and Shigeyoshi Fujimoto and Naoki Yamamoto},
  journal={International Reviews of Immunology},
  year={2008},
  volume={27},
  pages={110 - 93}
}
Natural killer (NK) cells recognize tumor cells and virus-infected cells and attack without being sensitized to antigens. The development of the antitumor/antivirus activities of NK cells is controlled by multiple mechanisms such as direct cytotoxic activity against target cells, antibody-dependent cell-mediated cytotoxicity, secretion of Th1-type cytokines, and interactions with dendritic cells. The development of these activities plays a significant role in both innate and adaptive immunities… 
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TLDR
This work has shown that NK cells display impaired functionality and capability to infiltrate tumors in cancer patients and multiple attempts currently aim to manipulate NK for utilization in the immunotherapy of cancer.
Natural Killer Cells in Cancer: An Overview
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Immunity monitoring studies that use cell surface marker analysis to determine NK cell numbers as a readout for efficacy of experimental therapies need to re-assess their NK cell detection strategy and differentially identify the different NK cell subsets.
The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction
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Mechanisms of suppression in the postoperative environment, including hypercoagulability, suppressive soluble factors, the expansion of suppressive cell populations, and how this affects NK cell biology are discussed, including modulation of cell surface receptors, the potential for anergy, and immunosuppressive NK cell functions.
Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells.
NK cell-based autologous immune enhancement therapy (AIET) for cancer
TLDR
The epidemiological data that show the relationship between NK activity and cancer incidence, monitoring of NK cell number and activity, anti-cancer activities of NK cells in vitro and in vivo and the effects of the combination of expanded NK cells with monoclonal antibody drugs on cancers through antibody-dependent cellular cytotoxicity are discussed.
Natural killer cell‐based immunotherapy in cancer: current insights and future prospects
TLDR
The status of NK cells in cancer patients, currently investigated clinical applications such as in vivo modulation of NK cell activity, ex vivo purification/expansion and adoptive transfer as well as future possibilities such as genetic modifications are discussed in detail.
Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor
TLDR
A bispecific single domain antibody (VHH) that targets CD16 (FcRγIII) on NK cells and the epidermal growth factor receptor (EGFR) on tumor cells can be used to target and enhance cytolysis of cancer cells.
Next-Generation Immunotherapies to Improve Anticancer Immunity
TLDR
A thorough understanding of the immune mechanism of the TME will lead to further development of more powerful therapeutic strategies, and strategies for improvement and possible immunotherapy combinations are reviewed.
Natural killer cells as a promising tool to tackle cancer—A review of sources, methodologies, and potentials
TLDR
The sources of such NK cells, methods for expansion, and the future potentials of taking the in vitro expanded allogeneic NK cells with good cytotoxic ability as a drug for treating cancer and/or viral infection and even as a prophylactic tool for prevention of cancer after initial remission are analyzed.
Enhancement of NK Cell Cytotoxicity against MDA-MB-231 Cell by Presence of OK432
TLDR
Overall the results suggested that OK432 has a vital role to play in NK cell augmentation for effective cell-mediated lysis.
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