Corpus ID: 89400049

Potential Niemann-Pick Type C Disease Therapeutics: Synthesis of Pyrrolinones and Enolate-Derived Thiadiazoles, and the Development of a Palladium-Catalyzed Alpha Alkenylation Reaction as a Means to Prepare Trichostatin A

@inproceedings{Cosner2011PotentialNT,
  title={Potential Niemann-Pick Type C Disease Therapeutics: Synthesis of Pyrrolinones and Enolate-Derived Thiadiazoles, and the Development of a Palladium-Catalyzed Alpha Alkenylation Reaction as a Means to Prepare Trichostatin A},
  author={C. Cosner},
  year={2011}
}
by Casey Charles Cosner Niemann-Pick type C disease (NPC) is a rare, fatal, autosomal recessive lipid storage disorder. There is currently no cure for NPC and very few treatment options exist. Working in collaboration with the Maxfield laboratory at the Cornell Medical School, we completed several projects aimed at discovering and developing potential therapeutic agents for the treatment of NPC. The first involved the identification of Naryl alkylidenepyrrolinones via high throughput screening… Expand