Potential Lipid-Lowering Effects of Eleusine indica (L) Gaertn. Extract on High-Fat-Diet-Induced Hyperlipidemic Rats

@article{Ong2017PotentialLE,
  title={Potential Lipid-Lowering Effects of Eleusine indica (L) Gaertn. Extract on High-Fat-Diet-Induced Hyperlipidemic Rats},
  author={Siew Ling Ong and Koteswara Rao Nalamolu and How Yee Lai},
  journal={Pharmacognosy Magazine},
  year={2017},
  volume={13},
  pages={S1 - S9}
}
Background: To date, anti-obesity agents based on natural products are tested for their potential using lipase inhibition assay through the interference of hydrolysis of fat by lipase resulting in reduced fat absorption without altering the central mechanisms. Previous screening study had indicated strong anti-obesity potential in Eleusine indica (E. indica), but to date, no pharmacologic studies have been reported so far. Objective: This study was performed to investigate the lipid-lowering… 
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References

SHOWING 1-10 OF 24 REFERENCES
Evaluation of anti-obesity effect of Aegle marmelos leaves.
TLDR
A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes.
Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor
TLDR
The anti-obesity effects of teasaponin in high-fat diet-treated mice may be partly mediated through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.
TLDR
The findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity and the observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them.
Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice
TLDR
PLE can inhibit the development of obesity and hyperlipidemia in high-fat diet induced obese mice and may be a novel appetite suppressant that only affects obesity owing to a high- fat diet.
IN VITRO LIPASE INHIBITORY EFFECT OF THIRTY TWO SELECTED PLANTS IN MALAYSIA
TLDR
Crude methanolic extracts of Eleusine indica, Myristica fragrans, Melastoma candidum and Phyla nodiflora were found to be possible candidates for further studies to isolate potential pancreatic lipase inhibitor among the thirty two different plants screened.
Anti-obesity potential of Clerodendron glandulosum.Coleb leaf aqueous extract.
TLDR
Coleb extract prevents adipocyte differentiation and visceral adiposity by down regulation of PPARγ-2 related genes and Lep expression thus validating its traditional therapeutic use in controlling obesity.
Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARα levels.
TLDR
It is suggested that kaempferol reduced the accumulation of visceral fat and improved hyperlipidemia in HFD-fed obese rats by increasing lipid metabolism through the downregulation of SREBPs and promoting the hepatic expression of ACO and CYP4A1, secondary to a direct upregulation hepatic PPAR α expression.
Eleucine indica Possesses Antioxidant, Antibacterial and Cytotoxic Properties
TLDR
Results demonstrate that the extract prepared from the EI possesses antioxidant activity in vitro in addition to antibacterial properties, which is needed to verify the antioxidant effects in vitro and in vivo.
Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats
TLDR
The results of this study indicate that the hepatoprotective effects of E. indica might be ascribable to its antioxidant and free radical scavenging property.
Screening of Some Medicinal Plants for their Pancreatic Lipase Inhibitory Potential
TLDR
Inhibition of the pancreatic lipase was chosen as the criteria for therapeutic efficacy since such inhibition would provide an adjunctive therapy to the pharmacological agents and minimize systemic adverse reactions by acting topically in the GI tract.
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