Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings

@article{Abbas2007PotentialIO,
  title={Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings},
  author={Ume L. Abbas and Roy M. Anderson and John W Mellors},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={904 - 911}
}
BACKGROUND The potential impact of pre-exposure chemoprophylaxis (PrEP) on heterosexual transmission of HIV-1 infection in resource-limited settings is uncertain. METHODOLOGY/PRINCIPLE FINDINGS A deterministic mathematical model was used to simulate the effects of antiretroviral PrEP on an HIV-1 epidemic in sub-Saharan Africa under different scenarios (optimistic, neutral and pessimistic) both with and without sexual disinhibition. Sensitivity analyses were used to evaluate the effect of… CONTINUE READING
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