Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings

  title={Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings},
  author={Ume L. Abbas and Roy M. Anderson and John W Mellors},
  journal={PLoS ONE},
  pages={904 - 911}
BACKGROUND The potential impact of pre-exposure chemoprophylaxis (PrEP) on heterosexual transmission of HIV-1 infection in resource-limited settings is uncertain. METHODOLOGY/PRINCIPLE FINDINGS A deterministic mathematical model was used to simulate the effects of antiretroviral PrEP on an HIV-1 epidemic in sub-Saharan Africa under different scenarios (optimistic, neutral and pessimistic) both with and without sexual disinhibition. Sensitivity analyses were used to evaluate the effect of… CONTINUE READING
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South African national HIV prevalence, HIV incidence, behavior and communication

  • O Shisana, T Rehle, L Simbayi, W Parker, K Zuma
  • 2005
Highly Influential
4 Excerpts

December 2006

  • UNAIDSWHO Epidemic Update
  • Available at: http:// data.unaids.org/pub…
  • 2007

AIDS drug provokes patent battle in India

  • A Gentleman, H Kumar
  • The International Herald Tribune
  • 2006
2 Excerpts

Blunted viraemia and slow drug resistance emergence in rhesus macaques failing chemoprophylaxis with emtricitabine

  • JG Garcı́a-Lerma, S Qari, R Otten, J Johnson, C Kim
  • Antivir Ther
  • 2006
2 Excerpts

Cost-effectiveness analysis of HIV chemoprophylaxis [Abstract THLB0102

  • R Grant, J Lama, P Goicochea, V Levy, T Porco
  • XVI International AIDS Conference
  • 2006
1 Excerpt

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