Potential Glucosamine‐Warfarin Interaction Resulting in Increased International Normalized Ratio: Case Report and Review of the Literature and MedWatch Database

@article{Knudsen2008PotentialGI,
  title={Potential Glucosamine‐Warfarin Interaction Resulting in Increased International Normalized Ratio: Case Report and Review of the Literature and MedWatch Database},
  author={James F. Knudsen and Gerald H. Sokol},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2008},
  volume={28}
}
  • J. F. Knudsen, G. Sokol
  • Published 1 April 2008
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
We describe a 71‐year‐old man who had received warfarin 7.5 mg/day for 5 years for atrial fibrillation, which had maintained his international normalized ratio (INR) within a narrow range of 2.5‐3.2. During this 5‐year period, he had also been treating himself with the supplement glucosamine hydrochloride 500 mg‐chondroitin sulfate 400 mg twice/day for arthritis. The patient then increased his dosage of glucosamine to 1500 mg and chondroitin to 1200 mg twice/day; his INR previous to this change… Expand
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