Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights

  title={Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights},
  author={Priyanka Singh and Ramesha H. Jayaramaiah and Sachin Bharat Agawane and Garikapati Vannuruswamy and Arvind M. Korwar and Atul Anand and Vitthal S. Dhaygude and Mahemud L. Shaikh and Rakesh S. Joshi and Ramanamurthy Boppana and Mahesh J Kulkarni and Hirekodathakallu V. Thulasiram and A. P. Giri},
  booktitle={Scientific reports},
Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites. Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. Major metabolites in O. kilimandscharicum, O. tenuiflorum, O. gratissimum were purified, characterized and evaluated for anti-glycation activity. In vitro inhibition of advanced glycation end products (AGEs) by eugenol was found to be highest. Preliminary biophysical analysis and blind docking studies to understand… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 7 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Maillard Proteomics: Opening New Pages

International journal of molecular sciences • 2017
View 2 Excerpts
Highly Influenced

The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature

Evidence-based complementary and alternative medicine : eCAM • 2017
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 44 references

Investigation of antiglycation activity of isoprenaline

Kolekar, M Y.
RSC Adv • 2015

Targeted quantification in prediabetic, diabetic and microalbuminuria plasma by parallel reaction monitoring, SWATH and MSE

Korwar, A. M. et al. Development of diagnostic fragment ion l albumin
Mol. Cell Proteomics 14, 2150–2159 • 2015

From reaction to intervention

M. J. Kulkarni, A. M. Korwar, +3 authors A. P. Glycated proteome
Proteomics Clin. Appl. 7, 155–170 • 2013

Similar Papers

Loading similar papers…