Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma

@inproceedings{Zdravkovic2014PotentialDI,
  title={Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma},
  author={Natasa D Zdravkovic and Ivan Jovanovic and Gordana D. Radosavljevic and Aleksandar N Arsenijevic and Nebojsa D. Zdravkovic and Slobodanka L. J. Mitrovic and Nebojsa N. Arsenijevic},
  booktitle={International journal of medical sciences},
  year={2014}
}
OBJECTIVE Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is multistep process that includes gene alterations of tumor suppressor genes, such as p53 and p16. The aim of this study was to investigate the expression patterns of p16, p53 and VEGF in affected tissue and serum levels of cytokines TNF-α, IFN-γ, IL-4, IL-6, IL-10 and IL-17 in patients with UC and CRC, respectively. MATHERIALS AND METHODS. Serum levels of cytokine in patients with UC (n=24) and CRC (n=75) and… CONTINUE READING