Potential Beneficial Effects of Probiotics on Human Migraine Headache: A Literature Review.

  title={Potential Beneficial Effects of Probiotics on Human Migraine Headache: A Literature Review.},
  author={Yu-jie Dai and Hong Wang and Xi-Jian Wang and Alan David Kaye and Yong-hai Sun},
  journal={Pain physician},
  volume={20 2},
BACKGROUND Recent studies have shown that migraine headache is often associated with concomitant gastrointestinal diseases. There is a higher prevalence of headaches in patients with gastrointestinal disorders. These associations between migraine and gastrointestinal disorders suggest a potential link to a bidirectional modulation of gut microbiota and brain function. The underlying working mechanistic links between migraine and gastrointestinal diseases may include increased intestinal… 

Tables from this paper

Probiotics for the Prophylaxis of Migraine: A Systematic Review of Randomized Placebo Controlled Trials

The heterogeneity of outcome measures used in the two trials included in this systematic review shows the need for a standardization of outcomes measures, therefore a series of recommendations for future probiotic–migraine research are included.

Effect of probiotic supplementation on migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials

A pooled analysis of available randomized controlled clinical trials showed that probiotic supplementation had no significant effect on the frequency and severity of episodic migraine attacks.

Microbiota-Pain Association; Recent Discoveries and Research Progress

The present study includes the most up-to-date and influential scientific findings on the association of microbiota with pain, despite the fact that the underlying mechanism is not identified in most cases.

Gut-brain Axis and migraine headache: a comprehensive review

It is proposed that migraine may be improved by dietary approaches with beneficial effects on gut microbiota and gut-brain axis including appropriate consumption of fiber per day, adhering to a low glycemic index diet, supplementation with vitamin D, omega-3 and probiotics as well as weight loss dietary plans for overweight and obese patients.

Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders

The view that KP modulation may provide common triggers for migraine and FGIDs with the involvement of TLR, AhR, and MyD88 activation is justified.

The missclassification of obesity affects the course of migraine

A lot of data support the idea that to overcome misclassifications of obese status, direct measurements of PBF, using dual energy x-ray absorptiometry (DXA), appears to be a better tool, respect all the anthropometric evaluations.

Pathophysiological Bases of Comorbidity in Migraine

The treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors.

A unique medium chain triglyceride-containing micronutrient complex: Effects on migraine symptoms compared to quality of life

Purpose: Migraine headaches and associated symptoms are prevalent medical issues. Medium-chain triglyceride (MCT)/nootropic-based compounds have demonstrated benefits in multiple domains. This study

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

This study suggests that the bioactive compounds found in WDT composition show potential in treating patients with neurological, psychiatric disorders, cardiovascular diseases, metabolic syndrome, and digestive disorders.



Migraine Associated with Gastrointestinal Disorders: Review of the Literature and Clinical Implications

An overview of the associations between migraine and GI disorders is presented, as well as possible mechanistic links and clinical implications, and a rationale to investigate the effects of the use of pre- and probiotics in migraine patients.

The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study.

Probiotics may decrease migraine supporting a possible role for the intestine in migraine management, and justify further placebo-controlled studies.

Dietary Considerations in Migraine Management: Does a Consistent Diet Improve Migraine?

A review of current data surrounding the issue of dietary consistency is presented from the perspective of migraine as an illness, as a disease, and with a view toward the role of local and systemic inflammation in its genesis.

Gut Microbiota and Brain Function: An Evolving Field in Neuroscience

A group of experts presented the symposium, “Gut microbiota and brain function: Relevance to psychiatric disorders” to review the latest findings in how gut microbiota may play a role in brain function, behavior, and disease, which covered a broad range of topics.

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.

The microbiota: an exercise immunology perspective.

Some preliminary experimental data obtained from animal studies or probiotics studies show some interesting results at the immune level, indicating that the microbiota also acts like an endocrine organ and is sensitive to the homeostatic and physiological changes associated with exercise.

Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

Daily subchronic administration of PF significantly reduced anxiety-like behaviour in rats and alleviated psychological distress in volunteers, as measured particularly by the HSCL-90 scale.

Consumption of fermented milk product with probiotic modulates brain activity.

Alterations in intrinsic activity of resting brain indicated that ingestion of FMPP was associated with changes in midbrain connectivity, which could explain the observed differences in activity during the task.

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

Gut microbiota acting through SCFAs are important determinants of enteric 5‐HT production and homeostasis through an effect of short‐chain fatty acids on enterochromaffin cells.

Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis.

The pooled evidence suggests that probiotics are associated with a reduction in AAD, and there exists significant heterogeneity in pooled results and the evidence is insufficient to determine whether this association varies systematically by population, antibiotic characteristic, or probiotic preparation.