Potential Association Between the Oral Tetracycline Class of Antimicrobials Used to Treat Acne and Inflammatory Bowel Disease

@article{Margolis2010PotentialAB,
  title={Potential Association Between the Oral Tetracycline Class of Antimicrobials Used to Treat Acne and Inflammatory Bowel Disease},
  author={David J. Margolis and Matthew Fanelli and Ole J. Hoffstad and James D. Lewis},
  journal={The American Journal of Gastroenterology},
  year={2010},
  volume={105},
  pages={2610-2616}
}
OBJECTIVES:Previous studies have shown an association between isotretinoin and inflammatory bowel disease (IBD). The majority of patients prescribed isotretinoin for their acne are previously on an extended course of antibiotics. Therefore, it is important to consider antibiotic use as a confounding variable for the development of IBD.METHODS:We performed a retrospective cohort study using The Health Improvement Network database of the United Kingdom. We identified 94,487 individuals with acne… 
Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study
TLDR
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TLDR
In prespecified secondary analyses, some evidence was found of associations with isotretinoin as well as topical acne medications, suggesting a possible association between IBD and acne itself, and additional research is needed to explore this possibility.
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TLDR
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TLDR
Clinicians should be cautious when prescribing certain antibiotic regimens to patients with a strong family history of IBD, it should be emphasized that available data are not granular enough to reach any definitive conclusions.
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TLDR
This study did not show an increased risk of IBD with prior isotretinoin use, and the risk seemed to be decreased, suggesting the anti-inflammatory and immune-modulating effects of isot retinoin may be worth exploring.
Oral Antibiotics for Acne
TLDR
Although oral antibiotics are one of the main options for moderate to severe acne, non-antibiotic therapy such as isotretinoin and hormonal therapies should be considered.
Treating acne with the tetracycline class of antibiotics: A review
TLDR
It is vital that the clinician understand the pros and cons of each tetracycline agent so as to optimally serve the acne population.
Acne antibiotic prescription pattern in Colombia.
TLDR
The antibiotic prescription pattern for acne vulgaris patients who were cared for the first time in 2015, and were prescribed with an antibiotic, no matter if it was topical, oral or both, is evaluated and compared against the Colombian clinical practice guidelines valid for that year in that country.
Acne antibiotic prescription pattern in Colombia.
TLDR
The antibiotic prescription pattern for acne vulgaris patients who were cared for the first time in 2015, and were prescribed with an antibiotic, no matter if it was topical, oral or both, is evaluated and compared against the Colombian clinical practice guidelines valid for that year in this country.
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