Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase.

@article{Bonasera2001PotentialB,
  title={Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase.},
  author={Thomas A Bonasera and Giuseppina Ortu and Yulia Rozen and Roman Krais and Nanette M. T. Freedman and Roland G Chisin and A Amatzia Gazit and Alexander Levitzki and Eyal Mishani},
  journal={Nuclear medicine and biology},
  year={2001},
  volume={28 4},
  pages={359-74}
}
As PET candidate tracers for EGFr-TK, five 4-(anilino)quinazoline derivatives, each fluorinated in the aniline moiety, were prepared. Each was tested in vitro for inhibition of EGFr autophosphorylation in A431 cell line. The leading compounds were then radiolabeled with (18)F and cell binding experiments, biodistribution and PET studies in A431 tumor… CONTINUE READING